{"id":3953,"date":"2020-03-16T00:43:34","date_gmt":"2020-03-15T21:43:34","guid":{"rendered":"https:\/\/by-tv.co.uk\/?p=3953"},"modified":"2020-03-16T00:59:30","modified_gmt":"2020-03-15T21:59:30","slug":"doc-dr-caghan-kizil-covid-19-icin-85-tane-ilac-gelistirme-calismasi-var","status":"publish","type":"post","link":"https:\/\/by-tv.co.uk\/en\/doc-dr-caghan-kizil-covid-19-icin-85-tane-ilac-gelistirme-calismasi-var\/","title":{"rendered":"N\u00f6robilimci ve Genetik\u00e7i Do\u00e7.Dr. \u00c7a\u011fhan K\u0131z\u0131l: COVID-19 i\u00e7in 85 tane ila\u00e7 geli\u015ftirme \u00e7al\u0131\u015fmas\u0131 var."},"content":{"rendered":"<p><strong><span class=\"css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\">*Do\u00e7. Dr. \u00c7a\u011fhan K\u0131z\u0131l<\/span><\/strong><br \/>\nDresden Teknik \u00dcniversitesi \u00d6\u011fretim \u00dcyesi<br \/>\nAlmanya N\u00f6rodejeneratif Hastal\u0131klar Merkezi<\/p>\n<p><span class=\"css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\">\u015eu anda veritabanlar\u0131ndaki bilgilere g\u00f6re COVID-19 i\u00e7in 85 tane ila\u00e7 geli\u015ftirme \u00e7al\u0131\u015fmas\u0131 var. Bunlar, ila\u00e7 geli\u015ftirme s\u00fcrecinin de\u011fi\u015fik a\u015famalar\u0131nda. %70&#8217;e yak\u0131n\u0131 &#8220;ke\u015fif&#8221; a\u015famas\u0131nda, %20 kadar\u0131 pre-klinik a\u015famada ve geri kalan\u0131 da klinik \u00e7al\u0131\u015fma safhalar\u0131nda.\u00a0<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3937 aligncenter\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2020\/03\/WhatsApp-Image-2020-03-14-at-19.53.25.jpeg\" alt=\"\" width=\"1600\" height=\"1066\" title=\"\"><\/p>\n<p>\u0130la\u00e7 geli\u015ftirmek i\u00e7in ilk a\u015fama Ke\u015fif a\u015famas\u0131. Burada bilimsel bir bilgiye dayanarak \u00fcretilen kimyasallar\u0131n belli ve \u00e7o\u011fu zaman basit bir tarama metodu ile taran\u0131p ilk adaylar\u0131n bulunmas\u0131 ger\u00e7ekle\u015fiyor.<\/p><div id=\"briti-1105710619\" class=\"briti-icerik\" style=\"margin-top: 5px;margin-bottom: 5px;\"><a href=\"https:\/\/piaryum.com\/services\/\" aria-label=\"piaryum banner\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2025\/12\/Gemini_Generated_Image_g5yqr1g5yqr1g5yq.jpg\" alt=\"\"  width=\"2064\" height=\"1152\"   \/><\/a><\/div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3956 aligncenter\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2020\/03\/ETGNOrPXgAcRQ6M.jpeg\" alt=\"\" width=\"680\" height=\"383\" title=\"\"><\/p>\n<p>2. a\u015fama pre-klinik \u00e7al\u0131\u015fma a\u015famas\u0131. Burada genelde hayvanlarda ve h\u00fccre k\u00fclt\u00fcrlerinde bir \u00f6nceki a\u015famada bulunan adaylar\u0131n farmakokinetik\/dinamik \u00f6zelliklerine bak\u0131l\u0131yor (emilim, metabolizma, da\u011f\u0131l\u0131m). insana verilecek dozlar belirleniyor ve g\u00fcvenilirli\u011fi \u00f6l\u00e7\u00fcl\u00fcyor.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3958 aligncenter\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2020\/03\/WhatsApp-Image-2020-03-15-at-21.20.16.jpeg\" alt=\"\" width=\"1600\" height=\"1066\" title=\"\"><\/p>\n<p>Pre-klinik a\u015famada bulunan adaylar klinik fazlara ge\u00e7iyor. \u0130lk fazlarda sa\u011fl\u0131kl\u0131 bireylerde dozlama analizleri ve yan etki profiline bak\u0131l\u0131yor. Sonraki a\u015famalarda hastalarda analiz edilen ilac\u0131n beklenen etkiyi yap\u0131p yapmad\u0131\u011f\u0131 inceleniyor.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3959 aligncenter\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2020\/03\/WhatsApp-Image-2020-03-15-at-21.20.16-3.jpeg\" alt=\"\" width=\"1600\" height=\"899\" title=\"\"><\/p>\n<p><span class=\"css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\">E\u011fer t\u00fcm bu s\u00fcre\u00e7ler ba\u015far\u0131l\u0131ysa ilaca onay veriliyor ve sonra piyasaya s\u00fcr\u00fclebiliyor. <\/span><span class=\"r-18u37iz\"><a class=\"css-4rbku5 css-18t94o4 css-901oao css-16my406 r-1n1174f r-1loqt21 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\" dir=\"ltr\" role=\"link\" href=\"https:\/\/twitter.com\/hashtag\/COVID%E3%83%BC19?src=hashtag_click\" data-focusable=\"true\" target=\"_blank\" rel=\"noopener\">#COVID\u30fc19<\/a><\/span><span class=\"css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\"> i\u00e7in bu s\u00fcre\u00e7lerin herhangi birinde olan maddeler vir\u00fcs\u00fcn \u00e7o\u011falmas\u0131n\u0131 \u00f6nlemeye, vir\u00fcs\u00fcn h\u00fccrelere girmesini engellemeye ya da ba\u011f\u0131\u015f\u0131kl\u0131k sistemini g\u00fc\u00e7lendirmeye dair. <\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3960 aligncenter\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2020\/03\/WhatsApp-Image-2020-03-15-at-21.20.16-2.jpeg\" alt=\"\" width=\"1600\" height=\"988\" title=\"\"><\/p>\n<p><span class=\"css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\">En son klinik safhada a\u015famas\u0131nda olan bir ila\u00e7 Remdesivir. Bir n\u00fckleotid benzeri madde olan Remdesivir Ebola ve Marburg vir\u00fcsleri i\u00e7in geli\u015ftirilmi\u015fti. Daha \u00f6nceki SARS ve MERS salg\u0131nlar\u0131nda da kullan\u0131lm\u0131\u015f, etkisi oldu\u011fu bildirilmi\u015fti.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.statnews.com\/pharmalot\/2020\/03\/13\/gilead-coronavirus-covid19-clinical-trials\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3954 aligncenter\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2020\/03\/49535193646_fb31d7da01_k-768x432.jpg\" alt=\"\" width=\"768\" height=\"432\" title=\"\"><\/a><\/p>\n<p><span class=\"css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\">Remdesivir a\u015f\u0131 de\u011fil. Etkisi s\u0131n\u0131rl\u0131 bir s\u00fcre i\u00e7in. Ancak <\/span><span class=\"r-18u37iz\"><a class=\"css-4rbku5 css-18t94o4 css-901oao css-16my406 r-1n1174f r-1loqt21 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\" dir=\"ltr\" role=\"link\" href=\"https:\/\/twitter.com\/hashtag\/COVID%E3%83%BC19?src=hashtag_click\" data-focusable=\"true\" target=\"_blank\" rel=\"noopener\">#COVID\u30fc19<\/a><\/span><span class=\"css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\"> i\u00e7in Washington eyaletinde kullan\u0131ld\u0131 .\u00c7in&#8217;e de g\u00f6nderildi ve \u015fu anda y\u00fcksek say\u0131da hasta \u00fczerinde deneniyor. ilac geli\u015fecekse en yak\u0131n\u0131 bu olabilir, fakat bu hen\u00fcz belirsiz\u00a0 <a href=\"https:\/\/www.statnews.com\/pharmalot\/2020\/03\/13\/gilead-coronavirus-covid19-clinical-trials\/\" target=\"_blank\" rel=\"noopener\">Link : 1<\/a><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3961 aligncenter\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2020\/03\/ETGM7EnWoAEgxFl-1.jpeg\" alt=\"\" width=\"680\" height=\"408\" title=\"\"><\/p>\n<p>Faz 1 a\u015famas\u0131nda baz\u0131 a\u015f\u0131 t\u00fcrevleri var. \u00d6rne\u011fin vir\u00fcs\u00fcn S proteinine antikor geli\u015ftirmek i\u00e7in uygulanan bir y\u00f6ntem. Bunun klini\u011fe yans\u0131mas\u0131 uzun zaman alabilir. Bu nedenle en erken a\u015f\u0131n\u0131n 1-2 sene i\u00e7inde olaca\u011f\u0131na dair a\u00e7\u0131klamalar yap\u0131ld\u0131 ge\u00e7en hafta i\u00e7inde<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3945 aligncenter\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2020\/03\/coronavirus-cells-in-microscopic-view-virus-from-MWG5AWQ-scaled.jpg\" alt=\"\" width=\"2560\" height=\"1195\" title=\"\"><\/p>\n<p><span class=\"css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\">Faz 2 a\u015famas\u0131nda da Danoprevir ve Favipiravir denen iki ila\u00e7 aday\u0131 var. Vir\u00fcs\u00fcn h\u00fccresel mekanizmalar\u0131n\u0131 bloke eden bu maddeler \u00e7o\u011falmay\u0131 \u00f6nlemeyi ama\u00e7l\u0131yor. Ancak erken safhalarda ve bunun i\u00e7in hastalarda denenmediler. Yani <\/span><span class=\"r-18u37iz\"><a class=\"css-4rbku5 css-18t94o4 css-901oao css-16my406 r-1n1174f r-1loqt21 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\" dir=\"ltr\" role=\"link\" href=\"https:\/\/twitter.com\/hashtag\/COVID%E3%83%BC19?src=hashtag_click\" data-focusable=\"true\" target=\"_blank\" rel=\"noopener\">#COVID\u30fc19<\/a><\/span><span class=\"css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0\"> i\u00e7in ila\u00e7 zaman alacak.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-3962\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2020\/03\/WhatsApp-Image-2020-03-15-at-21.32.01.jpeg\" alt=\"\" width=\"1600\" height=\"1067\" title=\"\"><\/p>\n<p>Bug\u00fcn haberlerde \u00e7\u0131kan Bel\u00e7ika&#8217;daki \u00e7al\u0131\u015fma umut verici, ancak antikor sadece laboratuvar deneyleri yapt\u0131klar\u0131 i\u00e7in \u00e7al\u0131\u015fman\u0131n ke\u015fif a\u015famas\u0131nda ya da erken pre-klinik a\u015famada oldu\u011fu anla\u015f\u0131l\u0131yor. Di\u011fer a\u015famalar\u0131 ge\u00e7ip klinik faza gelmesi gerekiyor.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3966 aligncenter\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2020\/03\/WhatsApp-Image-2020-03-15-at-21.31.48.jpeg\" alt=\"\" width=\"1600\" height=\"1067\" title=\"\">\u0130la\u00e7 geli\u015ftirme a\u015famalar\u0131 ba\u015f\u0131ndan sonuna ortalama 10-15 senelik bir s\u00fcre\u00e7 olabilir. Bu bize \u015funu \u00f6\u011fretiyor: vir\u00fcs\u00fcn salg\u0131n \u00f6ncesi yay\u0131lmas\u0131n\u0131 azaltmak ve sosyal temas\u0131 minimuma indirgemek, hijyen ve do\u011fru resmi kararlar ile de birle\u015fince elimizdeki en etkili yol.<\/p>\n<blockquote class=\"twitter-tweet\">\n<p dir=\"ltr\" lang=\"tr\">\u015eu anda veritabanlar\u0131ndaki bilgilere g\u00f6re COVID-19 i\u00e7in 85 tane ila\u00e7 geli\u015ftirme \u00e7al\u0131\u015fmas\u0131 var. Bunlar, ila\u00e7 geli\u015ftirme s\u00fcrecin\u0131n de\u011fi\u015fik a\u015famalar\u0131nda. %70&#8217;e yak\u0131n\u0131 &#8220;ke\u015fif&#8221; a\u015famas\u0131nda, %20 kadar\u0131 pre-klinik a\u015famada ve geri kalan\u0131 da klinik \u00e7al\u0131\u015fma safhalar\u0131nda. <a href=\"https:\/\/twitter.com\/hashtag\/coronavirus?src=hash&amp;ref_src=twsrc%5Etfw\" target=\"_blank\" rel=\"noopener\">#coronavirus<\/a> <a href=\"https:\/\/t.co\/fLxMegMkB3\">pic.twitter.com\/fLxMegMkB3<\/a><\/p>\n<p>\u2014 Caghan Kizil (@CaKizil) <a href=\"https:\/\/twitter.com\/CaKizil\/status\/1238927692260675586?ref_src=twsrc%5Etfw\" target=\"_blank\" rel=\"noopener\">March 14, 2020<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<div id=\"briti-2200105882\" class=\"briti-icerikten-sonra_2\" style=\"margin-top: 25px;margin-bottom: 25px;\"><a href=\"https:\/\/wa.me\/message\/NDZLLIOQT4H3O1\" aria-label=\"bytv reklam banner\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2025\/12\/bytv-reklam-banner.jpg\" alt=\"\"  width=\"2376\" height=\"1008\"   \/><\/a><\/div>","protected":false},"excerpt":{"rendered":"<p>*Do\u00e7. Dr. \u00c7a\u011fhan K\u0131z\u0131l Dresden Teknik \u00dcniversitesi \u00d6\u011fretim \u00dcyesi Almanya N\u00f6rodejeneratif Hastal\u0131klar Merkezi \u015eu anda veritabanlar\u0131ndaki bilgilere g\u00f6re COVID-19 i\u00e7in 85 tane ila\u00e7 geli\u015ftirme \u00e7al\u0131\u015fmas\u0131 var. Bunlar, ila\u00e7 geli\u015ftirme s\u00fcrecinin de\u011fi\u015fik a\u015famalar\u0131nda. %70&#8217;e yak\u0131n\u0131 &#8220;ke\u015fif&#8221; a\u015famas\u0131nda, %20 kadar\u0131 pre-klinik a\u015famada ve geri kalan\u0131 da klinik \u00e7al\u0131\u015fma safhalar\u0131nda.\u00a0 \u0130la\u00e7 geli\u015ftirmek i\u00e7in ilk a\u015fama Ke\u015fif a\u015famas\u0131. Burada bilimsel bir bilgiye dayanarak \u00fcretilen kimyasallar\u0131n belli ve \u00e7o\u011fu zaman basit bir tarama metodu ile taran\u0131p ilk adaylar\u0131n bulunmas\u0131 ger\u00e7ekle\u015fiyor. 2. a\u015fama pre-klinik \u00e7al\u0131\u015fma a\u015famas\u0131. Burada genelde hayvanlarda ve h\u00fccre k\u00fclt\u00fcrlerinde bir \u00f6nceki a\u015famada bulunan adaylar\u0131n farmakokinetik\/dinamik \u00f6zelliklerine bak\u0131l\u0131yor (emilim, metabolizma, da\u011f\u0131l\u0131m). insana verilecek dozlar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3955,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[1],"tags":[812,810,809,808,811,807,588,806],"class_list":["post-3953","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genel","tag-asi-calismalari","tag-caghan-kizil","tag-corona","tag-covid-19","tag-dresden-teknik-universitesi","tag-genetik","tag-koronavirus","tag-norobilim"],"_links":{"self":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts\/3953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/comments?post=3953"}],"version-history":[{"count":0,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts\/3953\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/media\/3955"}],"wp:attachment":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/media?parent=3953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/categories?post=3953"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/tags?post=3953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}