{"id":35208,"date":"2026-01-09T12:54:52","date_gmt":"2026-01-09T12:54:52","guid":{"rendered":"https:\/\/by-tv.co.uk\/?p=35208"},"modified":"2026-01-09T12:54:52","modified_gmt":"2026-01-09T12:54:52","slug":"alzheimer-tedavisinde-yeni-umut-apoe-geni","status":"publish","type":"post","link":"https:\/\/by-tv.co.uk\/en\/alzheimer-tedavisinde-yeni-umut-apoe-geni\/","title":{"rendered":"Alzheimer tedavisinde yeni umut: Apoe geni"},"content":{"rendered":"<div id=\"model-response-message-contentr_cd911b6258e5a314\" class=\"markdown markdown-main-panel enable-updated-hr-color\" dir=\"ltr\" aria-live=\"off\" aria-busy=\"false\">\n<p data-path-to-node=\"2\">Alzheimer hastal\u0131\u011f\u0131na y\u00f6nelik geli\u015ftirilecek yeni tedavilerin, hastal\u0131kla do\u011frudan ba\u011flant\u0131l\u0131 belirli bir geni hedef almas\u0131 gerekti\u011fi \u00f6ne s\u00fcr\u00fcld\u00fc. Ara\u015ft\u0131rmac\u0131lar, bu genin zararl\u0131 etkilerinin ortadan kald\u0131r\u0131lmas\u0131 halinde vakalar\u0131n b\u00fcy\u00fck \u00e7o\u011funun hi\u00e7 ortaya \u00e7\u0131kmayabilece\u011fini savunuyor.<\/p>\n<p data-path-to-node=\"3\"><b data-path-to-node=\"3\" data-index-in-node=\"0\">The Guardian\u2019\u0131n<\/b> haberine g\u00f6re, bu \u00e7a\u011fr\u0131, beyindeki toksik proteinleri temizleyerek hastalar\u0131 tedavi etmeyi ama\u00e7layan ilk ila\u00e7 dalgas\u0131n\u0131n ard\u0131ndan geldi. Mevcut ila\u00e7lar hastal\u0131\u011f\u0131 yava\u015flatsa da sa\u011flad\u0131klar\u0131 faydalar\u0131n k\u00fc\u00e7\u00fck g\u00f6r\u00fclmesi nedeniyle Birle\u015fik Krall\u0131k Ulusal Sa\u011fl\u0131k ve Bak\u0131m M\u00fckemmelli\u011fi Enstit\u00fcs\u00fc (<b data-path-to-node=\"3\" data-index-in-node=\"306\">NICE<\/b>) taraf\u0131ndan yayg\u0131n kullan\u0131m i\u00e7in reddedilmi\u015fti.<\/p>\n<p data-path-to-node=\"4\">Alternatif tedaviler arayan <b data-path-to-node=\"4\" data-index-in-node=\"28\">UCL<\/b> (University College London) bilim insanlar\u0131, ila\u00e7 geli\u015ftiricilerin <b data-path-to-node=\"4\" data-index-in-node=\"99\">Apoe<\/b> adl\u0131 genin riski art\u0131ran iki varyant\u0131na odaklanmas\u0131 gerekti\u011fini s\u00f6yl\u00fcyor. Bu varyantlar\u0131n etkisini engellemek \u00fczere tasarlanan tedavilerin, hastal\u0131\u011f\u0131 \u00f6nleme konusunda &#8220;<b data-path-to-node=\"4\" data-index-in-node=\"272\">b\u00fcy\u00fck potansiyele<\/b>&#8221; sahip oldu\u011fu iddia ediliyor.<\/p><div id=\"briti-1653328672\" class=\"briti-icerik\" style=\"margin-top: 5px;margin-bottom: 5px;\"><a href=\"https:\/\/piaryum.com\/services\/\" aria-label=\"piaryum banner\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2025\/12\/Gemini_Generated_Image_g5yqr1g5yqr1g5yq.jpg\" alt=\"\"  width=\"2064\" height=\"1152\"   \/><\/a><\/div>\n<h4 data-path-to-node=\"5\"><b data-path-to-node=\"5\" data-index-in-node=\"0\">Risk ta\u015f\u0131yan varyantlar: Apoe3 ve Apoe4<\/b><\/h4>\n<p data-path-to-node=\"6\"><b data-path-to-node=\"6\" data-index-in-node=\"0\">Dr. Dylan Williams<\/b> ve ekibi, Alzheimer hastal\u0131\u011f\u0131n\u0131n ne kadar\u0131n\u0131n Apoe geninin farkl\u0131 varyantlar\u0131ndan kaynakland\u0131\u011f\u0131n\u0131 hesaplamak i\u00e7in Avrupa k\u00f6kenli <b data-path-to-node=\"6\" data-index-in-node=\"148\">450.000<\/b>&#8216;den fazla ki\u015finin t\u0131bbi kay\u0131tlar\u0131n\u0131 analiz etti. \u0130nsanlar her ebeveynden birer tane olmak \u00fczere genin iki kopyas\u0131n\u0131 miras al\u0131yor ve genin \u00fc\u00e7 ana varyant\u0131 bulunuyor: <b data-path-to-node=\"6\" data-index-in-node=\"321\">Apoe2<\/b>, <b data-path-to-node=\"6\" data-index-in-node=\"328\">3<\/b> ve <b data-path-to-node=\"6\" data-index-in-node=\"333\">4<\/b>.<\/p>\n<p data-path-to-node=\"7\">Bilim insanlar\u0131 uzun zamand\u0131r iki <b data-path-to-node=\"7\" data-index-in-node=\"34\">Apoe4<\/b> kopyas\u0131na sahip ki\u015filerin Alzheimer i\u00e7in y\u00fcksek risk ta\u015f\u0131d\u0131\u011f\u0131n\u0131 biliyor. Ancak <b data-path-to-node=\"7\" data-index-in-node=\"119\">Apoe3<\/b> varyant\u0131 n\u00f6tr, nadir g\u00f6r\u00fclen <b data-path-to-node=\"7\" data-index-in-node=\"154\">Apoe2<\/b> varyant\u0131 ise koruyucu olarak kabul ediliyor.<\/p>\n<h4 data-path-to-node=\"8\"><b data-path-to-node=\"8\" data-index-in-node=\"0\">Vakalar\u0131n b\u00fcy\u00fck k\u0131sm\u0131 \u00f6nlenebilir<\/b><\/h4>\n<p data-path-to-node=\"9\">Williams, Apoe2&#8217;nin iki kopyas\u0131n\u0131 ta\u015f\u0131maya k\u0131yasla hem <b data-path-to-node=\"9\" data-index-in-node=\"55\">Apoe3<\/b> hem de <b data-path-to-node=\"9\" data-index-in-node=\"68\">Apoe4<\/b>&#8216;\u00fcn riski art\u0131rd\u0131\u011f\u0131n\u0131 belirtiyor. Ekip, bu varyantlar olmasayd\u0131 Alzheimer vakalar\u0131n\u0131n <b data-path-to-node=\"9\" data-index-in-node=\"159\">%72 ile %93<\/b> aras\u0131n\u0131n ve t\u00fcm demans vakalar\u0131n\u0131n yakla\u015f\u0131k <b data-path-to-node=\"9\" data-index-in-node=\"215\">%45<\/b>&#8216;inin ger\u00e7ekle\u015fmeyece\u011fini hesapl\u0131yor.<\/p>\n<p data-path-to-node=\"10\">Ancak bu yakla\u015f\u0131m baz\u0131 zorluklar bar\u0131nd\u0131r\u0131yor. <b data-path-to-node=\"10\" data-index-in-node=\"47\">Apoe<\/b> geni, kolesterol ve di\u011fer ya\u011flar\u0131n v\u00fccut ve beyin \u00e7evresinde ta\u015f\u0131nmas\u0131 i\u00e7in hayati \u00f6nem ta\u015f\u0131yor, bu nedenle geni tamamen devre d\u0131\u015f\u0131 b\u0131rakmak ba\u015fka sa\u011fl\u0131k sorunlar\u0131na yol a\u00e7abilir. Ayr\u0131ca Cenevre \u00dcniversitesi&#8217;nden <b data-path-to-node=\"10\" data-index-in-node=\"265\">Prof. Tim Frayling<\/b> gibi baz\u0131 uzmanlar, insanlar\u0131n <b data-path-to-node=\"10\" data-index-in-node=\"315\">%99<\/b>&#8216;unun riskli gen versiyonlar\u0131n\u0131 ta\u015f\u0131d\u0131\u011f\u0131n\u0131, bu nedenle endi\u015feye gerek olmad\u0131\u011f\u0131n\u0131 savunuyor.<\/p>\n<h4 data-path-to-node=\"11\"><b data-path-to-node=\"11\" data-index-in-node=\"0\">NHS\u2019de hen\u00fcz test mevcut de\u011fil<\/b><\/h4>\n<p data-path-to-node=\"12\">Edinburgh \u00dcniversitesi&#8217;nden <b data-path-to-node=\"12\" data-index-in-node=\"28\">Prof. Tara Spires-Jones<\/b> ise beyni Alzheimer&#8217;a kar\u015f\u0131 savunmas\u0131z hale getiren risk fakt\u00f6rlerini anlaman\u0131n etkili tedaviler geli\u015ftirmek i\u00e7in &#8220;<b data-path-to-node=\"12\" data-index-in-node=\"167\">gerekli<\/b>&#8221; oldu\u011funu vurguluyor.<\/p>\n<p data-path-to-node=\"13\"><b data-path-to-node=\"13\" data-index-in-node=\"0\">Alzheimer&#8217;s Research UK<\/b>&#8216;den <b data-path-to-node=\"13\" data-index-in-node=\"28\">Dr. Sheona Scales<\/b>, bulgular\u0131n \u00f6nemli sorular ortaya att\u0131\u011f\u0131n\u0131 ancak Apoe3 varyant\u0131n\u0131n risk \u00fczerindeki etkisinin daha \u00f6nce n\u00f6tr san\u0131ld\u0131\u011f\u0131n\u0131 belirtti. Alzheimer riskinin karma\u015f\u0131kl\u0131\u011f\u0131 nedeniyle, gelecekteki risklerinden endi\u015fe eden ki\u015filer i\u00e7in <b data-path-to-node=\"13\" data-index-in-node=\"269\">NHS<\/b>&#8216;de (Ulusal Sa\u011fl\u0131k Sistemi) hen\u00fcz Apoe testi mevcut de\u011fil. Uzmanlar, endi\u015fe duyan ki\u015filerin pratisyen hekimleriyle g\u00f6r\u00fc\u015fmesini tavsiye ediyor.<\/p>\n<\/div>\n<div id=\"briti-3684477221\" class=\"briti-icerikten-sonra_2\" style=\"margin-top: 25px;margin-bottom: 25px;\"><a href=\"https:\/\/wa.me\/message\/NDZLLIOQT4H3O1\" aria-label=\"bytv reklam banner\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2025\/12\/bytv-reklam-banner.jpg\" alt=\"\"  width=\"2376\" height=\"1008\"   \/><\/a><\/div>","protected":false},"excerpt":{"rendered":"<p>Alzheimer hastal\u0131\u011f\u0131na y\u00f6nelik geli\u015ftirilecek yeni tedavilerin, hastal\u0131kla do\u011frudan ba\u011flant\u0131l\u0131 belirli bir geni hedef almas\u0131 gerekti\u011fi \u00f6ne s\u00fcr\u00fcld\u00fc. Ara\u015ft\u0131rmac\u0131lar, bu genin zararl\u0131 etkilerinin ortadan kald\u0131r\u0131lmas\u0131 halinde vakalar\u0131n b\u00fcy\u00fck \u00e7o\u011funun hi\u00e7 ortaya \u00e7\u0131kmayabilece\u011fini savunuyor. The Guardian\u2019\u0131n haberine g\u00f6re, bu \u00e7a\u011fr\u0131, beyindeki toksik proteinleri temizleyerek hastalar\u0131 tedavi etmeyi ama\u00e7layan ilk ila\u00e7 dalgas\u0131n\u0131n ard\u0131ndan geldi. Mevcut ila\u00e7lar hastal\u0131\u011f\u0131 yava\u015flatsa da sa\u011flad\u0131klar\u0131 faydalar\u0131n k\u00fc\u00e7\u00fck g\u00f6r\u00fclmesi nedeniyle Birle\u015fik Krall\u0131k Ulusal Sa\u011fl\u0131k ve Bak\u0131m M\u00fckemmelli\u011fi Enstit\u00fcs\u00fc (NICE) taraf\u0131ndan yayg\u0131n kullan\u0131m i\u00e7in reddedilmi\u015fti. Alternatif tedaviler arayan UCL (University College London) bilim insanlar\u0131, ila\u00e7 geli\u015ftiricilerin Apoe adl\u0131 genin riski art\u0131ran iki varyant\u0131na odaklanmas\u0131 gerekti\u011fini s\u00f6yl\u00fcyor. Bu varyantlar\u0131n etkisini engellemek [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":35209,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[13],"tags":[],"class_list":["post-35208","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"_links":{"self":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts\/35208","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/comments?post=35208"}],"version-history":[{"count":1,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts\/35208\/revisions"}],"predecessor-version":[{"id":35210,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts\/35208\/revisions\/35210"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/media\/35209"}],"wp:attachment":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/media?parent=35208"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/categories?post=35208"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/tags?post=35208"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}