{"id":33946,"date":"2025-12-02T15:10:18","date_gmt":"2025-12-02T15:10:18","guid":{"rendered":"https:\/\/by-tv.co.uk\/?p=33946"},"modified":"2025-12-02T15:10:18","modified_gmt":"2025-12-02T15:10:18","slug":"bir-zayiflama-ignesi-alzheimerda-ilerlemeyi-yavaslatti","status":"publish","type":"post","link":"https:\/\/by-tv.co.uk\/en\/bir-zayiflama-ignesi-alzheimerda-ilerlemeyi-yavaslatti\/","title":{"rendered":"Bir zay\u0131flama i\u011fnesi alzheimer\u2019da ilerlemeyi yava\u015flatt\u0131"},"content":{"rendered":"<p><strong>Imperial College London<\/strong>\u2019dan <strong>Prof. Paul Edison<\/strong> liderli\u011finde y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fma, diyabet tedavisinde de kullan\u0131lan <strong>liraglutide<\/strong> adl\u0131 ilac\u0131n Alzheimer hastalar\u0131nda beyin hacmi kayb\u0131n\u0131 yakla\u015f\u0131k <strong>%50<\/strong> oran\u0131nda yava\u015flatt\u0131\u011f\u0131n\u0131 g\u00f6sterdi.<\/p>\n<p>Prof. Edison, bulgular\u0131n GLP-1 s\u0131n\u0131f\u0131 ila\u00e7lar\u0131n hastal\u0131\u011f\u0131n seyrini de\u011fi\u015ftirebilece\u011fine dair \u201c<strong>\u015fimdiye kadarki en g\u00fc\u00e7l\u00fc kan\u0131tlardan baz\u0131lar\u0131<\/strong>\u201d oldu\u011funu belirterek \u015fu ifadeleri kulland\u0131:<\/p>\n<p>\u201c<strong>Liraglutide<\/strong>, Faz 2b \u00e7al\u0131\u015fmam\u0131zda beyin yap\u0131s\u0131 \u00fczerinde olumlu etkiler ve bili\u015fsel gerilemeyi yava\u015flatma potansiyeli g\u00f6sterdi. Bu sonu\u00e7lar Faz 3 program\u0131n\u0131n yolunu a\u00e7t\u0131.\u201d<\/p><div id=\"briti-3503868457\" class=\"briti-icerik\" style=\"margin-top: 5px;margin-bottom: 5px;\"><a href=\"https:\/\/piaryum.com\/services\/\" aria-label=\"piaryum banner\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2025\/12\/Gemini_Generated_Image_g5yqr1g5yqr1g5yq.jpg\" alt=\"\"  width=\"2064\" height=\"1152\"   \/><\/a><\/div>\n<p>LBC&#8217;nin haberine g\u00f6re ilac\u0131n h\u00e2lihaz\u0131rda diyabet i\u00e7in onaylanm\u0131\u015f olmas\u0131n\u0131n b\u00fcy\u00fck avantaj oldu\u011funu vurgulayan Edison, Alzheimer i\u00e7in geli\u015ftirme s\u00fcrecinin \u201c<strong>s\u0131f\u0131rdan yeni bir tedavi \u00fcretmekten \u00e7ok daha h\u0131zl\u0131<\/strong>\u201d ilerleyebilece\u011fini s\u00f6yledi.<\/p>\n<h4>Alternatif tedavi yakla\u015f\u0131m\u0131<\/h4>\n<p>Prof. Edison, bu y\u00f6ntemin yaln\u0131zca Alzheimer\u2019da klasik hedef olan <strong>amiloid proteini<\/strong> \u00fczerine odaklanmad\u0131\u011f\u0131n\u0131, tamamen farkl\u0131 bir tedavi stratejisini test etti\u011fini kaydetti.<\/p>\n<p>GLP-1 resept\u00f6r agonistleri olarak bilinen enjeksiyonlar, i\u015ftah\u0131 azaltarak kilo kayb\u0131 sa\u011fl\u0131yor ve NHS\u2019te y\u00fcksek BMI\u2019ya sahip hastalara re\u00e7ete ediliyor. <strong>Semaglutide (Wegovy, Ozempic)<\/strong>, <strong>tirzepatide (Mounjaro)<\/strong> ve <strong>liraglutide (Saxenda)<\/strong> bu ila\u00e7 grubunun bilinen \u00f6rnekleri aras\u0131nda.<\/p>\n<h4>Kansere kar\u015f\u0131 ek faydalar da ara\u015ft\u0131r\u0131l\u0131yor<\/h4>\n<p>May\u0131s ay\u0131nda <strong>eClinicalMedicine<\/strong> dergisinde yay\u0131mlanan bir \u00e7al\u0131\u015fma, liraglutide ve exenatide gibi ilk nesil GLP-1 agonistlerinin kilo kayb\u0131 d\u0131\u015f\u0131nda <strong>anti-kanser etkiler<\/strong> de g\u00f6sterebilece\u011fini ortaya koydu.<\/p>\n<p>\u00c7al\u0131\u015fman\u0131n e\u015f yazar\u0131, Tel Aviv\u2019deki <strong>Clalit Health Services<\/strong>\u2019ten <strong>Dr. Yael Wolff Sagy<\/strong>, ilac\u0131n yaln\u0131zca zay\u0131flama etkisiyle a\u00e7\u0131klanamayan ve <strong>obeziteyle ili\u015fkili kanserleri \u00f6nlemede %41 daha etkili<\/strong> g\u00f6r\u00fcnen do\u011frudan bir biyolojik etkiden bahsedildi\u011fini s\u00f6yledi.<\/p>\n<h4>Alzheimer denemesinde dikkat \u00e7ekici sonu\u00e7lar<\/h4>\n<p>Son \u00e7al\u0131\u015fmada, ya\u015f ortalamas\u0131 71 olan <strong>169 hafif veya orta d\u00fczey Alzheimer hastas\u0131<\/strong> iki gruba ayr\u0131ld\u0131. <strong>72 ki\u015fi liraglutide<\/strong>, <strong>82 ki\u015fi ise placebo<\/strong> ald\u0131.<\/p>\n<p>Bir y\u0131l boyunca yap\u0131lan bir\u00e7ok beyin taramas\u0131, <strong>liraglutide kullanan hastalarda beyin hacmi kayb\u0131n\u0131n placebo grubuna k\u0131yasla yakla\u015f\u0131k yar\u0131 yar\u0131ya azald\u0131\u011f\u0131n\u0131<\/strong> ortaya koydu.<\/p>\n<p>Uzmanlar, bu bulgular\u0131n Alzheimer tedavisinde yeni bir d\u00f6nemin kap\u0131s\u0131n\u0131 aralayabilece\u011fini belirtiyor.<\/p>\n<div id=\"briti-2777679684\" class=\"briti-icerikten-sonra_2\" style=\"margin-top: 25px;margin-bottom: 25px;\"><a href=\"https:\/\/wa.me\/message\/NDZLLIOQT4H3O1\" aria-label=\"bytv reklam banner\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/by-tv.co.uk\/wp-content\/uploads\/2025\/12\/bytv-reklam-banner.jpg\" alt=\"\"  width=\"2376\" height=\"1008\"   \/><\/a><\/div>","protected":false},"excerpt":{"rendered":"<p>Imperial College London\u2019dan Prof. Paul Edison liderli\u011finde y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fma, diyabet tedavisinde de kullan\u0131lan liraglutide adl\u0131 ilac\u0131n Alzheimer hastalar\u0131nda beyin hacmi kayb\u0131n\u0131 yakla\u015f\u0131k %50 oran\u0131nda yava\u015flatt\u0131\u011f\u0131n\u0131 g\u00f6sterdi. Prof. Edison, bulgular\u0131n GLP-1 s\u0131n\u0131f\u0131 ila\u00e7lar\u0131n hastal\u0131\u011f\u0131n seyrini de\u011fi\u015ftirebilece\u011fine dair \u201c\u015fimdiye kadarki en g\u00fc\u00e7l\u00fc kan\u0131tlardan baz\u0131lar\u0131\u201d oldu\u011funu belirterek \u015fu ifadeleri kulland\u0131: \u201cLiraglutide, Faz 2b \u00e7al\u0131\u015fmam\u0131zda beyin yap\u0131s\u0131 \u00fczerinde olumlu etkiler ve bili\u015fsel gerilemeyi yava\u015flatma potansiyeli g\u00f6sterdi. Bu sonu\u00e7lar Faz 3 program\u0131n\u0131n yolunu a\u00e7t\u0131.\u201d LBC&#8217;nin haberine g\u00f6re ilac\u0131n h\u00e2lihaz\u0131rda diyabet i\u00e7in onaylanm\u0131\u015f olmas\u0131n\u0131n b\u00fcy\u00fck avantaj oldu\u011funu vurgulayan Edison, Alzheimer i\u00e7in geli\u015ftirme s\u00fcrecinin \u201cs\u0131f\u0131rdan yeni bir tedavi \u00fcretmekten \u00e7ok daha h\u0131zl\u0131\u201d ilerleyebilece\u011fini s\u00f6yledi. Alternatif tedavi yakla\u015f\u0131m\u0131 [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":33948,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[11,13],"tags":[],"class_list":["post-33946","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya","category-saglik"],"_links":{"self":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts\/33946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/comments?post=33946"}],"version-history":[{"count":1,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts\/33946\/revisions"}],"predecessor-version":[{"id":33949,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts\/33946\/revisions\/33949"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/media\/33948"}],"wp:attachment":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/media?parent=33946"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/categories?post=33946"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/tags?post=33946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}