{"id":31382,"date":"2025-05-24T03:17:40","date_gmt":"2025-05-24T02:17:40","guid":{"rendered":"https:\/\/by-tv.co.uk\/?p=31382"},"modified":"2025-05-24T03:17:40","modified_gmt":"2025-05-24T02:17:40","slug":"kanser-riski-tasiyan-donorden-67den-fazla-cocuk-dunyaya-geldi","status":"publish","type":"post","link":"https:\/\/by-tv.co.uk\/en\/kanser-riski-tasiyan-donorden-67den-fazla-cocuk-dunyaya-geldi\/","title":{"rendered":"Kanser Riski Ta\u015f\u0131yan Don\u00f6rden 67’den Fazla \u00c7ocuk D\u00fcnyaya Geldi"},"content":{"rendered":"

Bir Avrupa sperm bankas\u0131 arac\u0131l\u0131\u011f\u0131yla kanser riski ta\u015f\u0131yan genetik mutasyona sahip bir don\u00f6rden al\u0131nan spermle en az 67 \u00e7ocu\u011fun d\u00fcnyaya geldi\u011fi ortaya \u00e7\u0131kt\u0131. The Guardian<\/em>\u2019\u0131n haberine g\u00f6re, bu \u00e7ocuklardan 10’u \u015fu ana kadar l\u00f6semi ve non-Hodgkin lenfoma dahil olmak \u00fczere \u00e7e\u015fitli kanser t\u00fcrlerine yakaland\u0131.<\/p>\n

Genetik Mutasyon Ge\u00e7 Fark Edildi<\/h4>\n

2008 ile 2015 y\u0131llar\u0131 aras\u0131nda do\u011fan \u00e7ocuklar\u0131 kapsayan bu vakada, ba\u011f\u0131\u015f\u00e7\u0131da bulunan nadir bir TP53 gen varyant\u0131n\u0131n sonradan Li-Fraumeni sendromu ile ili\u015fkili oldu\u011fu anla\u015f\u0131ld\u0131. Bu sendrom, kal\u0131tsal kanser e\u011filiminin en a\u011f\u0131r bi\u00e7imlerinden biri olarak kabul ediliyor.<\/p>\n

Fransa\u2019daki Rouen \u00dcniversitesi Hastanesi’nde g\u00f6rev yapan biyolog Dr. Edwige Kasper, vakay\u0131 \u0130talya\u2019n\u0131n Milano kentinde d\u00fczenlenen Avrupa \u0130nsan Geneti\u011fi Derne\u011fi (ESHG) y\u0131ll\u0131k konferans\u0131nda sundu. Kasper, \u201cHer sperm ba\u011f\u0131\u015f\u00e7\u0131s\u0131na t\u00fcm genom taramas\u0131 yap\u0131lmas\u0131n\u0131 savunmuyorum. Ancak bu, genetik bir hastal\u0131\u011f\u0131n ola\u011fan d\u0131\u015f\u0131 yay\u0131l\u0131m\u0131d\u0131r. Her erkek Avrupa genelinde 75 \u00e7ocuk sahibi olmamal\u0131,\u201d dedi.<\/p>

\"\"<\/a><\/div>\n

TP53 varyant\u0131, ba\u011f\u0131\u015f s\u0131ras\u0131nda bilinen bir risk fakt\u00f6r\u00fc de\u011fildi ve standart tarama y\u00f6ntemleriyle tespit edilemezdi. Don\u00f6r\u00fcn sa\u011fl\u0131k durumunun h\u00e2len iyi oldu\u011fu ifade ediliyor. Ancak Kasper\u2019in laboratuvar\u0131nda yap\u0131lan analizler, varyant\u0131n muhtemelen kansere neden oldu\u011funu ve bu ba\u011f\u0131\u015f\u00e7\u0131dan do\u011fan \u00e7ocuklar\u0131n genetik dan\u0131\u015fmanl\u0131k almas\u0131 gerekti\u011fini ortaya koydu.<\/p>\n

Sekiz \u00dclkede 46 Aile Etkilendi<\/h4>\n

Vakaya ilk olarak, \u00e7ocuklar\u0131nda benzer kanser vakalar\u0131 g\u00f6r\u00fclen iki ailenin kendi do\u011furganl\u0131k kliniklerine ba\u015fvurmas\u0131yla dikkat \u00e7ekildi. Daha sonra Avrupa genelindeki pediatri ve genetik birimleri benzer vakalar\u0131 ara\u015ft\u0131rmaya ba\u015flad\u0131. Sekiz Avrupa \u00fclkesindeki 46 ailede toplam 67 \u00e7ocuk test edildi ve 23\u2019\u00fcnde s\u00f6z konusu genetik varyanta rastland\u0131. Bu \u00e7ocuklardan 10\u2019u ise kansere yakaland\u0131.<\/p>\n

Riskli gene sahip \u00e7ocuklara d\u00fczenli t\u00fcm v\u00fccut ve beyin MR\u2019\u0131, yeti\u015fkinlikte ise meme MR\u2019\u0131 ve kar\u0131n ultrasonu ile takip \u00f6neriliyor.<\/p>\n

Ba\u011f\u0131\u015f\u00e7\u0131 S\u0131n\u0131rlar\u0131 Tart\u0131\u015fma Konusu<\/h4>\n

Avrupa Sperm Bankas\u0131, bir ba\u011f\u0131\u015f\u00e7\u0131n\u0131n sperminden maksimum 75 ailede \u00e7ocuk sahibi olunmas\u0131na izin verdi\u011fini belirtiyor. Ancak bu ba\u011f\u0131\u015f\u00e7\u0131dan do\u011fan \u00e7ocuk say\u0131s\u0131n\u0131n 67\u2019nin \u00fczerinde oldu\u011fu tahmin edilse de, kurum kesin say\u0131 vermekten ka\u00e7\u0131n\u0131yor. Dr. Kasper, \u201cGer\u00e7ek say\u0131 67 mi? Bu, sperm bankas\u0131na y\u00f6neltti\u011fim ama net yan\u0131t alamad\u0131\u011f\u0131m bir soru,\u201d dedi.<\/p>\n

De Montfort \u00dcniversitesi\u2019nden Prof. Nicky Hudson, olay\u0131n insan \u00fcreme h\u00fccrelerinin uluslararas\u0131 ta\u015f\u0131n\u0131m\u0131yla birlikte gelen zorluklar\u0131 g\u00f6zler \u00f6n\u00fcne serdi\u011fini vurgulad\u0131. Hudson, bu t\u00fcr durumlar\u0131n sosyal ve t\u0131bbi a\u00e7\u0131dan izlenmesinin olduk\u00e7a karma\u015f\u0131k oldu\u011funu ifade etti.<\/p>\n

Uzmanlar, benzer durumlar\u0131n \u00f6n\u00fcne ge\u00e7ebilmek ad\u0131na Avrupa genelinde ortak bir ba\u011f\u0131\u015f\u00e7\u0131 s\u0131n\u0131r\u0131 belirlenmesi gerekti\u011fi g\u00f6r\u00fc\u015f\u00fcnde birle\u015fiyor.<\/p>\n

\"\"<\/a><\/div>","protected":false},"excerpt":{"rendered":"

Bir Avrupa sperm bankas\u0131 arac\u0131l\u0131\u011f\u0131yla kanser riski ta\u015f\u0131yan genetik mutasyona sahip bir don\u00f6rden al\u0131nan spermle en az 67 \u00e7ocu\u011fun d\u00fcnyaya geldi\u011fi ortaya \u00e7\u0131kt\u0131. The Guardian\u2019\u0131n haberine g\u00f6re, bu \u00e7ocuklardan 10’u \u015fu ana kadar l\u00f6semi ve non-Hodgkin lenfoma dahil olmak \u00fczere \u00e7e\u015fitli kanser t\u00fcrlerine yakaland\u0131. Genetik Mutasyon Ge\u00e7 Fark Edildi 2008 ile 2015 y\u0131llar\u0131 aras\u0131nda do\u011fan \u00e7ocuklar\u0131 kapsayan bu vakada, ba\u011f\u0131\u015f\u00e7\u0131da bulunan nadir bir TP53 gen varyant\u0131n\u0131n sonradan Li-Fraumeni sendromu ile ili\u015fkili oldu\u011fu anla\u015f\u0131ld\u0131. Bu sendrom, kal\u0131tsal kanser e\u011filiminin en a\u011f\u0131r bi\u00e7imlerinden biri olarak kabul ediliyor. Fransa\u2019daki Rouen \u00dcniversitesi Hastanesi’nde g\u00f6rev yapan biyolog Dr. Edwige Kasper, vakay\u0131 \u0130talya\u2019n\u0131n Milano kentinde d\u00fczenlenen […]<\/p>\n","protected":false},"author":1,"featured_media":31383,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[5269],"tags":[],"class_list":["post-31382","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-birlesik-krallik"],"_links":{"self":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts\/31382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/comments?post=31382"}],"version-history":[{"count":0,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/posts\/31382\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/media\/31383"}],"wp:attachment":[{"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/media?parent=31382"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/categories?post=31382"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/by-tv.co.uk\/en\/wp-json\/wp\/v2\/tags?post=31382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}